THYRAGE is a EC funded H2020 research project that will investigate the effects of thyroid hormone on a wide range of age-related diseases, including osteoporosis, osteoarthritis, neurological disorders and sarcopenia. Knowledge generated in this innovative project is needed to develop new strategies to prevent and treat these diseases in the elderly.

University of Naples "Federico II"

Naples, Italy
The Department of Clinical Medicine and Surgery is located in the Medical Campus of the University of Naples "Federico II", a widely recognized world-leading centre of excellence in all aspects of medical education and research.

The team led by Professor Salvatore is actively engaged in both clinical and basic endocrine research. The basic research focuses on deciphering fundamental aspects of TH action, in particular the role of the iodothyronine deiodinases Dio1, Dio2 and Dio3 in different organs and tissues. Over the last decade, the laboratory has strongly developed its basic research on the role of intracellular thyroid metabolism in muscle physiology and muscle stem cell behaviour, while maintaining an excellent international reputation for its clinical endocrinology practice.

The main focus of the University of Naples will be the role of intracellular TH metabolism in muscle stemm cells and muscle wasting processes during age-related diseases.

Prof. Domenico Salvatore

Coordinator of Laboratory of Molecular Endocrinology
Department of Clinical Medicine and Surgery, University of Naples

Domenico Salvatore, associate Professor at the University of Naples Federico II is the Coordinator of and person responsible for the "Laboratory of Molecular Endocrinology". Furthermore he is the supervisor of Master and PhD students as well as supervisor of visiting undergraduate students, technical staff and post-doctoral scientists. He began research on TH metabolism in 1993 at the Thyroid Division, Harvard Medical School. From 1996 to 2000, he underwent training for the Residency in Clinical Endocrinology. In October 2001 he obtained a research position at the Department of Molecular and Cellular Endocrinology and Oncology, University of Naples "Federico II". During this time he carried out research both in vivo and in vitro, which has resulted in articles in peer reviewed journals. His scientific activity can be divided into two main areas: i) Molecular mechanisms of thyroid carcinogenesis and gene expression; ii) Peripherial metabolism of TH and the role of seleno-deiodinases.

Monica Dentice

Independent investigator
Department of Clinical Medicine and Surgery, University of Naples

Monica Dentice, independent investigator with a long-standing experience of TH metabolism studies. She graduated in Biological Science in 1998 at University of Naples "Federico II" and got her PhD in General Pathology in 2005. Since 2010, she started to actively working as an independent PI coordinating a team of young fellows and students, in close collaboration with Professor Salvatore's lab. She is the first author of the recent publication in JCI on the role of D2 in muscle regeneration and is currently actively working on the role of deiodinases in muscle atrophy. The close interaction with Professor Salvatore's lab constitues a unique stimulatin environment that will foster the growth and exploitation of frontier ideas in TH metabolism.

Caterina Miro

PhD candidate
Department of Clinical Medicine and Surgery, University of Naples

Caterina Miro studied Biological Science at University of Naples, Federico II. In November 2016, she started her phD project on the role of thyroid hormone in the accelerated protein breakdown process during atrophic conditions. She is focused on the molecular mechanism by which TH modulates muscle physiology, with the aim of finding a therapeutic treatment of muscle atrophy.

M. Angela De Stefano, MB

PhD candidate
Department of Clinical Medicine and Surgery, University of Naples
M.Angela De Stefano is graduated at Medical Biotechnology University of Naples in Italy. Her PhD project focus on the role of deiodinases during atrophic processes such as cachexia, denervation and fasting. The aim of this study is to provide new knowledge on the potential role of thyroid hormone modulators for the treatment of muscle-related diseases.