The focus of The Molecular Endocrinology Group, Dept. of Medicine, UK-ICL in this project will be to determine the roles of TH in age-related degeneration of bone and joints using sophisticated inducible tissue-specific Cre-Lox gene-targeting approaches. In the last 12 years students and post-docs supervised by Graham Williams and Duncan Bassett in the Molecular Endocrinology Laboratory have won more than 30 prizes and awards at national and international meetings for their research.
Prof. Graham R. Williams
Graham R. Williams, Professor of Endocrinology and consultant endocrinologist graduated in Medicine from St. Thomas's Hospital Medical School, University of London, obtained his PhD from University of Birmingham and undertook postdoctoral research at Harvard Medical School. He has been the recipient of the American Thyroid Association Sidney H. Ingbar Award (2014), Danish Thyroid Association Distinguished Lectureship (2014), European Thyroid Association Merck-Serono Prize (2012) and Society for Endocrinology Medal (2011).
His research focuses on the pathophysiological mechanisms of TH action in the skeleton using genetically modified mice and more recently on the development of novel complementary phenotyping techniques for detailed analysis of mouse bone and joints. He has published more than 130 peer reviewed papers and has supervised 15 PhD students.
Prof. J.H. Duncan Bassett
J.H. Duncan Bassett, Professor of Endocrinology and consultant in metabolic bone desease gradutated in Medicine from Cambridge and Oxford Universities and obtained his PhD from Imperial College London. His current research is directed towards the; (i) development and validation of high-througput bone and joint phenotyping platforms to analyse mice generated by the Wellcome Trust Sanger Mouse Genetics Project for the International Knockout Mouse Consortium, (ii) generation and characterisation of mice with chondrocyte, osteoblast or osteoclast specific deltion of TH to determine the molecular and cellular basis of T3 action during skeletal development and in adult bone. He has published more than 60 peer reviewed papers and has supervised 6 PhD students.
Michael Dack, Research Technician, graduated in Biochemistry from the University of Bath. Michael undertook a research placement in the Bone Biology division at the Garvan Institute of Medical Research, Sydney, Australia, before joining the Molecular Endocrinology Laboratory in September 2019. Michael’s current role involves assisting research into the effect of hypothyroidism in cell-specific osteoporosis and osteoarthritis models.
Siobhan Guilfoyle, Research Technician, graduated in Biochemistry from the University of Bath. Siobhan undertook a research placement in the Bone Biology division at the Garvan Institute of Medical Research, Sydney, Australia, before joining the Molecular Endocrinology Laboratory in August 2019. Siobhan’s current role involves assisting research into the effect of hypothyroidism in cell-specific osteoporosis and osteoarthritis models.