THYRAGE is a EC funded H2020 research project that will investigate the effects of thyroid hormone on a wide range of age-related diseases, including osteoporosis, osteoarthritis, neurological disorders and sarcopenia. Knowledge generated in this innovative project is needed to develop new strategies to prevent and treat these diseases in the elderly.


Popularised publication: Hyponieuws, 16 April 2016. Levensverwachting en schildklier

Dr. Tóth Miklós et all, Nervous system related mechanism underlying the development of the Low T3 Syndrome. Article in journal Magyar Belorvosi Archivum, 2016. 


Bos MM, Smit RAJ, Trompet S, van Heemst D, Noordam R. Thyroid Signaling, Insulin Resistance, and 2 Diabetes Mellitus: A Mendelian Randomization Study. Journal of Clin Endocrinol Metab. (June 1, 2017, doi: 10.1210/jc.2016-2816)

Gereben B, Fekete C. Nervous system related mechanism underlying the development of the Low T3 Syndrome. Magyar Belorvosi Archivum (

Gothié JD, Demeneix B, Remaud S. Comparative approaches to understanding thyroid hormone regulation of neurogenesis. Molecular and Cellular Endocrinology (May 22, 2017; doi: 10.1016/j.mce.2017.05.020) 

Gothié JD, Sébillot A, Luongo C, Legendre M, Nguyen Van C, Le Blay K, Perret-Jeanneret M, Remaud S, Demeneix B.A. Adult neural stem cell fate is determined by thyroid hormone activation of mitochondrial metabolism. Molecular Metabolism. (doi: 1010.1016/j.molmet.2017.08.003)

Hameed S, Patterson M, Dhillo WS, Rahman SA, Yue Ma, Holton C, Gogakos A, Yeo GSH, Lam BYH, Polex-Wolf J, Fenske W, Bell J, Anastasovska J, Samarut J, Bloom SR, Bassett JHD, Williams GR, Gardiner JV. Thyroid Hormone Receptor Beta in the Ventromedial Hypothalamus Is Essential for the Physiological Regulation of Food Intake and Body Weight. Cell Reports. (Jun 13;19(11):2202-2209. doi: 10.1016/j.celrep.2017.05.066)

Leitch VD, Di Cosmo C, Liao XH, O'Boy S, Galliford TM, Evans H, Croucher PI, Boyde A, Dumitrescu A, Weiss RE, Refetoff S, Williams GR, Bassett JHD. An essential physiological role for MCT8 in bone in male mice. Endocrinology. (Jun 15, 2017. doi: 10.1210/en.2017-00399)

Remaud S, Ortiz F, Perret-Jeanneret M, Aigrot MS, Gothié JD, Fekete C, Kvárta-Papp Z, Gereben B, Langui D, Lubetzki C, Angulo M, Zalc B, Demeneix B. Transient hypothyroidism favors oligodendrocyte generation providing functional remyelination in the adult mouse brain. eLife, eLife Sciences Publication (2017, doi: 10.7554/eLife.29996.001)

van Vliet N, van der Spoel E, Beekman M, Slagboom E, Blauw GJ, Gussekloo J, Westendorp R, van Heemst D. Thyroid status and mortality in nonagenarians from long-lived families and the general population. Aging (2017, doi: 10.18632/aging.101310)


Vliet van NA, Noordam R, Klinken van JB, Westendorp RGJ, Bassett JHD, Williams GR, Heemst van D. Thyroid Stimulating Hormone and Bone Mineral Density: Evidence From a Two-Sample Mendelian Randomization Study and a Candidate Gene Association Study. Journal of Bone and Mineral Research (2018, doi: 10.1022/jbmr.3426)

Williams G, Bassett D. Thyroid diseases and bone health. Journal of Endocrinological Investigation (2018, doi: 10.1007/s40618-017-0753-4)

Wopereis D, Du Puy R, van Heemst D, Walsh J, Bremner A, Bakker S, Bauer D, Cappola A, Ceresini G, Degryse J, Dullaart R, Feller M, Ferrucci L, Floriani C, Franco O, Iacoviello M, Iervasi G, Imaizumi M, Jukema W, Khaw KT, Luben R, Molinaro S, Nauck M, Patel K, Peeters R, Psaty B, Razvi S, Schindhelm K, van Schoor N, Stoo D, Vaes B, Vanderpump M, Volzke H, Westendorp R, Rodondi N, Cobbaert C, Gussekloo J, den Elzen W. The Relation Between Thyroid Function and Anemia: A Pooled Analysis of Individual Participant Data. The Journal of Clinical Endocrinology & Metabolism (2018, doi: 10.1210/jc.2018-00481)

Bianco AC, Dumitrescu A, Gereben B, Ribeiro MO, Fonseca TL, Fernandes GW, Bocco BMLC. Paradigms of Dynamic Control of Thyroid Hormone Signaling. Endocr Rev. (2019 Aug 1;40(4):1000-1047. doi: 10.1210/er.2018-00275)

Fonseca TL, Fernandes GW, Bocco BMLC, Keshavarzian A, Jakate S, Donohue TM Jr, Gereben B, Bianco AC. Hepatic Inactivation of the Type 2 Deiodinase Confers Resistance to Alcoholic Liver Steatosis. Alcohol Clin Exp Res. (2019 Jul;43(7):1376-1383. doi: 10.1111/acer.14027. Epub 2019 Apr 26)

Jo S, Fonseca T, Bocco B, Fernandes G, McAninch E, Bolin A, Da Conceicao R, Werneck-de-Castro JP, Ignacio D, Egri P, Németh D, Fekete C, Bernardi MM, Leitch V, Mannan N, Curry K, Butterfield N, Bassett D, Williams G, Gereben B, Ribeiro M, Bianco A. Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain. Journal of Clinical Investigation (2019, doi: 10.1172/jci123176)

Leitch VD, Brassill MJ, Rahman S, Butterfield NC, Ma P, Logan JG, Boyde A, Evans H, Croucher PI, Batterham RL, Williams GR, Bassett JHD. PYY is a negative regulator of bone mass and strength.
Bone. 2019 Oct;127:427-435. doi: 10.1016/j.bone.2019.07.011. Epub 2019 Jul 12. PubMed PMID: 31306808; PubMed Central PMCID: PMC6715792.

Miro C, Di Cicco E, Ambrosio R, Mancino G, Di Girolamo D, Cicatiello AG, Sagliocchi S, Nappi A, De Stefano MA, Luongo C, Antonini D, Visconte F, Varricchio S, Ilardi G, Del Vecchio L, Staibano S, Boelen A, Blanpain C, Missero C, Salvatore D, Dentice M. Thyroid hormone induces progression and invasiveness of squamous cell carcinomas by promoting a ZEB-1/E-cadherin switch. Nat Commun. 2019 Nov 27;10(1):5410. doi: 10.1038/s41467-019-13140-2. Erratum in: Nat Commun. 2020 Jan 8;11(1):245. PubMed PMID: 31776338; PubMed Central PMCID: PMC6881453.

Sagliocchi S, Cicatiello AG, Di Cicco E, Ambrosio R, Miro C, Di Girolamo D, Nappi A, Mancino G, De Stefano MA, Luongo C, Raia M, Ogawa-Wong AN, Zavacki AM, Paladino S, Salvatore D, Dentice M.
The thyroid hormone activating enzyme, type 2 deiodinase, induces myogenic differentiation by regulating mitochondrial metabolism and reducing oxidative stress. Redox Biol. 2019 Jun;24:101228. doi: 10.1016/j.redox.2019.101228. Epub 2019 May 22. PubMed PMID: 31153038; PubMed Central PMCID: PMC6543119.

van der Spoel E, Oei N, Cachucho R, Roelfsema F, Berbée F, Blauw GJ, Pijl H, Appelman-Dijkstra N, van Heemst D. The 24-hour serum profiles of bone markers in healthy older men and women. Bone (2019, doi: 10.1016/j.bone.2018.10.002) 

van der Spoel E, Choi J, Roelfsema F, Cessie SL, van Heemst D, Dekkers OM. Comparing Methods for Measurement Error Detection in Serial 24-h Hormonal Data. J Biol Rhythms. 2019 Aug;34(4):347-363. doi: 10.1177/0748730419850917. Epub 2019 Jun 12. PubMed PMID: 31187683; PubMed Central PMCID: PMC6637814.

van der Spoel E, van Vliet NA, van Heemst D. Viewpoint on the role of tissue maintenance in ageing: focus on biomarkers of bone, cartilage, muscle, and brain tissue maintenance. Ageing Res Rev. 2019 Dec;56:100964. doi:10.1016/j.arr.2019.100964. Epub 2019 Sep 24. Review. PubMed PMID: 31561015.

Vancamp P, Gothié JD, Luongo C, Sébillot A, Le Blay K, Butruille L, Pagnin M, Richardson SJ, Demeneix BA, Remaud S. Gender-specific effects of transthyretin on neural stem cell fate in the subventricular zone of the adult mouse. Sci Rep. 2019 Dec 23;9(1):19689. doi: 10.1038/s41598-019-56156-w. PubMed PMID: 31873158; PubMed Central PMCID: PMC6927974.

Gothié JD, Vancamp P, Demeneix B, Remaud S. Thyroid hormone regulation of neural stem cell fate: From development to ageing. Acta Physiol (Oxf). 2020 Jan;228(1):e13316. doi: 10.1111/apha.13316. Epub 2019 Jun 17. Review. PubMed PMID: 31121082.

Zutinic A, Pijl H, Ballieux BE, Roelfsema F, Westendorp RGJ, Blauw GJ, van Heemst D. Familial Longevity is Associated with an Attenuated Thyroidal Response to Recombinant Human Thyroid Stimulating Hormone. J Clin Endocrinol Metab. 2020 Apr 18. pii: dgaa195. doi: 10.1210/clinem/dgaa195.