THYRAGE is a EC funded H2020 research project that will investigate the effects of thyroid hormone on a wide range of age-related diseases, including osteoporosis, osteoarthritis, neurological disorders and sarcopenia. Knowledge generated in this innovative project is needed to develop new strategies to prevent and treat these diseases in the elderly.

Centre National de la Recherche Scientifique

Paris, France
CNRS is a state-funded science and technology establishment placed under the authorithy of the French Minister for Research. CNRS research units are located throughout France and employ a large body of tenured researchers, engineers and support staff. Laboratories are all on renewable four-year contracts, with bi-annual evaluation.

The Joint Research Unit "Evolution of Endocrine Regulations" is affiliated with the CNRS and the National Muséum of Natural History. Research focuses on nuclear receptors and development, exemplified by its role in the FP6 project CRESCENDO and FP7 projects SWITCHBOX and HUMAN. Besides being involved in the Exploitation Monitoring Board, main focus of CNRS will be the control of TH availability in the adult neural stem cell niche and cell specific delivery of TH modulators in the stem cell niche, using both in vivo delivery methods and in vitro neurosphere cultures.
 

Prof. Barbara Demeneix

Professor, Team leader
CNRS

Prof. Barbara Demeneix has a noteworthy track-record in basic and translational research (over 170 publications in endocrinology and physiology) as well as in leading and managing international and national research consortia. She was coordinator (till February 2015) of SWITCHBOX, an EU Integrated Project addressing the role of central, hypothalamic control of metabolism in ageing. She was one of the recipients of the CNRS medal for Innovation in 2014 and the Nature Mentoring Award for France in 2011.

Dr. Sylvie Remaud

Assistant professor
CNRS

Dr. Sylvie Remaud has TH regulation of the neural stemm cell niche, notably commitment of precursor populations during aging, as main research focus.

Dr. Lucile Butruille

Post-doctoral position
CNRS

Dr Lucile Butruille obtained her doctorate in neuroendocrinology at the National Institute of the Agronomic Research (INRA). Her PhD was focused on the characterization and the role of the hypothalamic neurogenic niche in sheep and mice, and its involvement in neuroendocrine control of adult reproductive function.
Her research aims to study the control of adult neurogenesis by thyroid hormones and their role in age-related diseases.

Anthony Sébillot

Research Assistant in Neuroendocrinology
CNRS

CNAM engineer from Paris, Anthony Sébillot began his career in 2004 by studying the neuronal-glial cell interactions in mice and the activity of deiodinases in the Xenopus model. In 2005, he joined WatchFrog and he has contributed to the development of an endocrine disruptors measurement tool and performed in vivo assays for water quality.

From 2012, he is R & D Project Manager at WatchFrog to develop in vivo tests for the detection and quantification of endocrine disruptors. His aim was to develop a sensitive and specific transgenic medaka (Oryzias latipes) model bearing an androgen responsive fluorescent reporter construct for whole organism-based environmental screening of (anti-)androgens, and contributed to the OECD Inter-laboratory validation of the Xenopus Embryonic Thyroid signalling Assay (XETA) designed for the detection of thyroid active compounds.
From 2016, his research aims to study the control of adult neurogenesis by thyroid hormones and their role in age-related diseases.