THYRAGE is a EC funded H2020 research project that will investigate the effects of thyroid hormone on a wide range of age-related diseases, including osteoporosis, osteoarthritis, neurological disorders and sarcopenia. Knowledge generated in this innovative project is needed to develop new strategies to prevent and treat these diseases in the elderly.

Is chemical pollution poisoning our brains?

published: 09-11-2017 12:48
That’s the question raised by the new TV documentary “Demain, tous crétins?” (Brains in danger?), which is due to be screened on the French and German television channel Arte on 11 November 2017.

In this 55-minute film, scientists explain how exposure to chemicals may affect normal brain development in children, especially during the first three months of pregnancy. In particular, the film highlights a laboratory study on tadpoles led by Prof. Barbara Demeneix, our THYRAGE principal investigator at CNRS and author of Toxic Cocktail (Oxford University Press, 2017) that largely inspired the documentary.
In her book, Barbara Demeneix presents evidence, derived from a wide spectrum of scientific and epidemiological studies, that many of these chemicals are interfering with one of our bodies' most essential regulators of brain development, thyroid hormone, but also offers number of recommendations for individuals to apply in their day-to-day life and suggests actions that should be taken at the regulatory level. The book was published in French in October 2017: Cocktail Toxique, Editions Odile Jacob.
The ideas presented in the book and film are relevant to Thyrage in that they address the questions of how chemical pollution affects brain development through interference with thyroid hormone action. Thyrage focuses on thyroid hormone action on stem cell population and ageing. This area has yet to be addressed in the context of chemical exposure could be exacerbating thyroid function and stem cell activity during ageing.

Teaser in French: (screened on 11 November 2017 at 10.30 pm CET).
Teaser in German: (screened on 11 November 2017 at 9.55 pm CET).
Barbara Demeneix’s books
Toxic Cocktail, how chemical pollution is poisoning our brains
Cocktail Toxique, comment les perturbateurs endocriniens empoisonnent notre cerveau