THYRAGE is a EC funded H2020 research project that will investigate the effects of thyroid hormone on a wide range of age-related diseases, including osteoporosis, osteoarthritis, neurological disorders and sarcopenia. Knowledge generated in this innovative project is needed to develop new strategies to prevent and treat these diseases in the elderly.

Imperial College London

London, United Kingdom
Imperial College London is a university of world class scholarship, education and research in science, engineering and medicine. It is consistently rated among the UK top three universities. The department of Medicine is one of the largest research organisations in the UK, with world-leading infrastructure supporting more than 200 principal investigators and their research laboratories .

The focus of The Molecular Endocrinology Group, Dept. of Medicine, UK-ICL in this project will be to determine the roles of TH in age-related degeneration of bone and joints using sophisticated inducible tissue-specific Cre-Lox gene-targeting approaches. In the last 12 years students and post-docs supervised by Graham Williams and Duncan Bassett in the Molecular Endocrinology Laboratory have won more than 30 prizes and awards at national and international meetings for their research.

Prof. Graham R. Williams

 Professor of Endocrinology and consultant endocrinologist
Imperial College London

Graham R. Williams, Professor of Endocrinology and consultant endocrinologist graduated in Medicine from St. Thomas's Hospital Medical School, University of London, obtained his PhD from University of Birmingham and undertook postdoctoral research at Harvard Medical School. He has been the recipient of the American Thyroid Association Sidney H. Ingbar Award (2014), Danish Thyroid Association Distinguished Lectureship (2014), European Thyroid Association Merck-Serono Prize (2012) and Society for Endocrinology Medal (2011).

His research focuses on the pathophysiological mechanisms of TH action in the skeleton using genetically modified mice and more recently on the development of novel complementary phenotyping techniques for detailed analysis of mouse bone and joints. He has published more than 130 peer reviewed papers and has supervised 15 PhD students.

Prof. J.H. Duncan Bassett

 Professor of Endocrinology and consultant in metabolic bone disease
Imperial College London

J.H. Duncan Bassett, Professor of Endocrinology and consultant in metabolic bone desease gradutated in Medicine from Cambridge and Oxford Universities and obtained his PhD from Imperial College London. His current research is directed towards the; (i) development and validation of high-througput bone and joint phenotyping platforms to analyse mice generated by the Wellcome Trust Sanger Mouse Genetics Project for the International Knockout Mouse Consortium, (ii) generation and characterisation of mice with chondrocyte, osteoblast or osteoclast specific deltion of TH to determine the molecular and cellular basis of T3 action during skeletal development and in adult bone. He has published more than 60 peer reviewed papers and has supervised 6 PhD students.