The focus of The Molecular Endocrinology Group, Dept. of Medicine, UK-ICL in this project will be to determine the roles of TH in age-related degeneration of bone and joints using sophisticated inducible tissue-specific Cre-Lox gene-targeting approaches. In the last 12 years students and post-docs supervised by Graham Williams and Duncan Bassett in the Molecular Endocrinology Laboratory have won more than 30 prizes and awards at national and international meetings for their research.
Prof. Graham R. Williams
Graham R. Williams, Professor of Endocrinology and consultant endocrinologist graduated in Medicine from St. Thomas's Hospital Medical School, University of London, obtained his PhD from University of Birmingham and undertook postdoctoral research at Harvard Medical School. He has been the recipient of the American Thyroid Association Sidney H. Ingbar Award (2014), Danish Thyroid Association Distinguished Lectureship (2014), European Thyroid Association Merck-Serono Prize (2012) and Society for Endocrinology Medal (2011).
His research focuses on the pathophysiological mechanisms of TH action in the skeleton using genetically modified mice and more recently on the development of novel complementary phenotyping techniques for detailed analysis of mouse bone and joints. He has published more than 130 peer reviewed papers and has supervised 15 PhD students.
Prof. J.H. Duncan Bassett
J.H. Duncan Bassett, Professor of Endocrinology and consultant in metabolic bone desease gradutated in Medicine from Cambridge and Oxford Universities and obtained his PhD from Imperial College London. His current research is directed towards the; (i) development and validation of high-througput bone and joint phenotyping platforms to analyse mice generated by the Wellcome Trust Sanger Mouse Genetics Project for the International Knockout Mouse Consortium, (ii) generation and characterisation of mice with chondrocyte, osteoblast or osteoclast specific deltion of TH to determine the molecular and cellular basis of T3 action during skeletal development and in adult bone. He has published more than 60 peer reviewed papers and has supervised 6 PhD students.
Anne studied Bioveterinary Sciences at the Royal Veterinary College, University of London graduating in 2015. After undertaking two lab projects utilising the STR/ort mouse model of spontaneous osteoarthritis in her BSc, she was enthusiastic to embark on a year-long Master’s research project to further investigate the aberrant immunophenotype of this model. What she has enjoyed most about THYRAGE so far is the chance to look at the development of bone and joint disease from a new perspective and learning how our collaborative efforts will help shape current understanding of the connection between different age-related disorders.
Naila studied a BSc in Biomedical Science (specialising in Endocrinology) and an MSc in Genes, Drugs and Stem cells – Novel Therapies at Imperial College London. For THYRAGE, she will be using genetically modified mice which are temporally inducible for cell-specific thyroid hormone manipulations. The effect of these manipulations will be investigated on joint phenotypes and disease pathogenesis of Osteoarthritis. For this, novel complementary phenotyping techniques for detailed analysis of mouse joints will be used. She is enthusiastic about contributing to such an exciting project and has the ultimate aim of helping to elucidate and thus alleviate age-related diseases of bone and joint. She believes that being healthy for as long as possible is one of the most important demands in such an ageing population.