THYRAGE is a EC funded H2020 research project that will investigate the effects of thyroid hormone on a wide range of age-related diseases, including osteoporosis, osteoarthritis, neurological disorders and sarcopenia. Knowledge generated in this innovative project is needed to develop new strategies to prevent and treat these diseases in the elderly.

The Institute of Experimental Medicine, Hungarian Academy of Sciences (IEM HAS)

Budapest, Hungary
The IEM HAS is the leading multidisciplinary neuroscience research centre in Central-Europe and received the Centre of Excellence Award from the EU. Its activity focuses on basic biomedical research, primarily in the field of neuroscience, including studies on neurotransmission, learning and memory, behaviour, ischaemic and epileptic brain damage, ageing as well as the central and peripheral control of hormone secretion. 


Two independant laboratories of the Institute will be involved in the THYRAGE project: the Laboratory of Integrative Neuroendocrinology and the Laboratory of Molecular Cell Metabolism. The two laboratories have complementary approaches to study TH metabolism and action: neuroanatomy, neurophysiology, cell biology, molecular neuroscience and transgenic approaches.

Main focus of IEM HAS will be the control of TH availability in the adult neural stem cell niche and the in vitro and in vivo testing the peptide-TH action modulator conjugates.

Prof. Csaba Fekete

Leader of the Laboratory of Integrative Neuroendocrinology
Institute of Experimental Medicine, Hungarian Academy of Sciences

Professor Csaba Fekete graduated at Albert Szent-Györgyi Medical University, Szeged, Hungary as a medical doctor. During his PhD studies he was trained as a neuroanatomist and neurophysiologist. He studied regulation of hypophysiotropic TRH neurones as a postdoctoral fellow at Tufts University Boston (MA) between 1998-2000. His primary research interest is to understand the central regulation of energy metabolism and the hypothalamic-pituitary-thyroid axis and elucidate the role of TH in the process of ageing. He published more than 90 peer reviewed articles and supervised 4 PhD students during the course of their successful PhD studies.

Prof. Balázs Gereben

Leader of the Laboratory of Molecular Cell Metabolism
Institute of Experimental Medicine, Hungarian Academy of Sciences

Professor Balázs Gereben graduated at the University of Veterinary Sciences, Budapest, Hungary as a veterinarian. During his PhD, he received training in molecular and cellular neurobiology. He studied molecular regulation of deiodinase enzymes as a postdoctoral fellow at the Harvard Medical School (Boston, MA) between 1998-2000. His primary research interest is to understand the molecular mechanisms and biological consequences of intracellular TH metabolism in the brain under physiological and pathophysiological conditions. He published over 55 peer reviewed articles.