Two independant laboratories of the Institute will be involved in the THYRAGE project: the Laboratory of Integrative Neuroendocrinology and the Laboratory of Molecular Cell Metabolism. The two laboratories have complementary approaches to study TH metabolism and action: neuroanatomy, neurophysiology, cell biology, molecular neuroscience and transgenic approaches.
Main focus of IEM HAS will be the control of TH availability in the adult neural stem cell niche and the in vitro and in vivo testing the peptide-TH action modulator conjugates.
Prof. Csaba Fekete
Professor Csaba Fekete graduated at Albert Szent-Györgyi Medical University, Szeged, Hungary as a medical doctor. During his PhD studies he was trained as a neuroanatomist and neurophysiologist. He studied regulation of hypophysiotropic TRH neurones as a postdoctoral fellow at Tufts University Boston (MA) between 1998-2000. His primary research interest is to understand the central regulation of energy metabolism and the hypothalamic-pituitary-thyroid axis and elucidate the role of TH in the process of ageing. He published more than 90 peer reviewed articles and supervised 4 PhD students during the course of their successful PhD studies.
Prof. Balázs Gereben
Professor Balázs Gereben graduated at the University of Veterinary Sciences, Budapest, Hungary as a veterinarian. During his PhD, he received training in molecular and cellular neurobiology. He studied molecular regulation of deiodinase enzymes as a postdoctoral fellow at the Harvard Medical School (Boston, MA) between 1998-2000. His primary research interest is to understand the molecular mechanisms and biological consequences of intracellular TH metabolism in the brain under physiological and pathophysiological conditions. He published over 55 peer reviewed articles.
Richárd Sinkó graduated as a bioengineer at the Budapest University of Technology and Economics and is presently a PhD student in the Laboratory of Prof. Balázs Gereben. His PhD project focuses on intracellular regulation of thyroid hormone signalling and he also has a deep interest in statistics and mathematical experiment designing. Richárd works on testing Pepscan developed compounds to modulate thyroid hormone action in cellular and in vivo models in order to provide cure for age-related tissue dysfunction. He is extremely motivated to contribute to a project with such marked translational potential, as THYRAGE.