THYRAGE is a EC funded H2020 research project that will investigate the effects of thyroid hormone on a wide range of age-related diseases, including osteoporosis, osteoarthritis, neurological disorders and sarcopenia. Knowledge generated in this innovative project is needed to develop new strategies to prevent and treat these diseases in the elderly.


Popularised publication: Hyponieuws, 16 April 2016. Levensverwachting en schildklier

Dr. Tóth Miklós et all, Nervous system related mechanism underlying the development of the Low T3 Syndrome. Article in journal Magyar Belorvosi Archivum, 2016. 


Bos MM, Smit RAJ, Trompet S, van Heemst D, Noordam R. Thyroid Signaling, Insulin Resistance, and 2 Diabetes Mellitus: A Mendelian Randomization Study. Journal of Clin Endocrinol Metab. (June 1, 2017, doi: 10.1210/jc.2016-2816)

Gereben B, Fekete C. Nervous system related mechanism underlying the development of the Low T3 Syndrome. Magyar Belorvosi Archivum (

Gothié JD, Demeneix B, Remaud S. Comparative approaches to understanding thyroid hormone regulation of neurogenesis. Molecular and Cellular Endocrinology (May 22, 2017; doi: 10.1016/j.mce.2017.05.020) 

Gothié JD, Sébillot A, Luongo C, Legendre M, Nguyen Van C, Le Blay K, Perret-Jeanneret M, Remaud S, Demeneix B.A. Adult neural stem cell fate is determined by thyroid hormone activation of mitochondrial metabolism. Molecular Metabolism. (doi: 1010.1016/j.molmet.2017.08.003)

Hameed S, Patterson M, Dhillo WS, Rahman SA, Yue Ma, Holton C, Gogakos A, Yeo GSH, Lam BYH, Polex-Wolf J, Fenske W, Bell J, Anastasovska J, Samarut J, Bloom SR, Bassett JHD, Williams GR, Gardiner JV. Thyroid Hormone Receptor Beta in the Ventromedial Hypothalamus Is Essential for the Physiological Regulation of Food Intake and Body Weight. Cell Reports. (Jun 13;19(11):2202-2209. doi: 10.1016/j.celrep.2017.05.066)

Leitch VD, Di Cosmo C, Liao XH, O'Boy S, Galliford TM, Evans H, Croucher PI, Boyde A, Dumitrescu A, Weiss RE, Refetoff S, Williams GR, Bassett JHD. An essential physiological role for MCT8 in bone in male mice. Endocrinology. (Jun 15, 2017. doi: 10.1210/en.2017-00399)

Remaud S, Ortiz F, Perret-Jeanneret M, Aigrot MS, Gothié JD, Fekete C, Kvárta-Papp Z, Gereben B, Langui D, Lubetzki C, Angulo M, Zalc B, Demeneix B. Transient hypothyroidism favors oligodendrocyte generation providing functional remyelination in the adult mouse brain. eLife, eLife Sciences Publication (2017, doi: 10.7554/eLife.29996.001)

van Vliet N, van der Spoel E, Beekman M, Slagboom E, Blauw GJ, Gussekloo J, Westendorp R, van Heemst D. Thyroid status and mortality in nonagenarians from long-lived families and the general population. Aging (2017, doi: 10.18632/aging.101310)


Vliet van NA, Noordam R, Klinken van JB, Westendorp RGJ, Bassett JHD, Williams GR, Heemst van D. Thyroid Stimulating Hormone and Bone Mineral Density: Evidence From a Two-Sample Mendelian Randomization Study and a Candidate Gene Association Study. Journal of Bone and Mineral Research (2018, doi: 10.1022/jbmr.3426)

Williams G, Bassett D. Thyroid diseases and bone health. Journal of Endocrinological Investigation (2018, doi: 10.1007/s40618-017-0753-4)

Wopereis D, Du Puy R, van Heemst D, Walsh J, Bremner A, Bakker S, Bauer D, Cappola A, Ceresini G, Degryse J, Dullaart R, Feller M, Ferrucci L, Floriani C, Franco O, Iacoviello M, Iervasi G, Imaizumi M, Jukema W, Khaw KT, Luben R, Molinaro S, Nauck M, Patel K, Peeters R, Psaty B, Razvi S, Schindhelm K, van Schoor N, Stoo D, Vaes B, Vanderpump M, Volzke H, Westendorp R, Rodondi N, Cobbaert C, Gussekloo J, den Elzen W. The Relation Between Thyroid Function and Anemia: A Pooled Analysis of Individual Participant Data. The Journal of Clinical Endocrinology & Metabolism (2018, doi: 10.1210/jc.2018-00481)

Jo S, Fonseca T, Bocco B, Fernandes G, McAninch E, Bolin A, Da Conceicao R, Werneck-de-Castro JP, Ignacio D, Egri P, Németh D, Fekete C, Bernardi MM, Leitch V, Mannan N, Curry K, Butterfield N, Bassett D, Williams G, Gereben B, Ribeiro M, Bianco A. Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain. Journal of Clinical Investigation (2019, doi: 10.1172/jci123176)

Spoel E, Oei N, Cachucho R, Roelfsema F, Berbée F, Blauw GJ, Pijl H, Appelman-Dijkstra N, van Heemst D. The 24-hour serum profiles of bone markers in healthy older men and women. Bone (2019, doi: 10.1016/j.bone.2018.10.002)