THYRAGE is a EC funded H2020 research project that will investigate the effects of thyroid hormone on a wide range of age-related diseases, including osteoporosis, osteoarthritis, neurological disorders and sarcopenia. Knowledge generated in this innovative project is needed to develop new strategies to prevent and treat these diseases in the elderly.

Bone Research Society 2018

published: 02-07-2018 16:16
Between the 27th and 29th of June 2018, THRYAGE investigators Professor Duncan Bassett, Naila Mannan and Anne Adoum from Imperial College London contributed to the Bone Research Society Annual Meeting. Duncan Bassett chaired a few talks including the oral communications and poster pitches on Thursday 28th June. It was hosted by the University of Southampton and took place at the University of Winchester. Many collaborators (from Europe and USA) attended and it was an excellent opportunity for networking.

The symposia included fascinating topics such as ageing; early life origins of disease; osteoporosis and sarcopenia; imaging; tissue engineering and regenerative medicine and clinical cases. There were also very interesting sessions such as the Rare Bone Disease workshop evening. In particular, the New Investigators Workshop was very useful as it aimed to help young researchers in their career progression and academic life; similar to the Young Investigators sessions held by THYRAGE.
Naila Mannan delivered a poster pitch, which summarised the key points of the poster and encouraged people to visit the poster for more information. Anne Adoum and Naila Mannan were giving more information and answering questions at the poster stand, to several delegates who showed interest. They also had time to visit other posters and learn about other aspects of bone research.

Out of the many interesting talks; Naila Mannan particularly enjoyed two talks which linked ageing and its associated morbidities with inflammation and cellular senescence. The idea of the ‘Geroscience hypothesis’ was the most exciting aspect. This hypothesis says that if you manipulate or intervene with ageing mechanisms, you can delay or decrease the severity of multiple “age-related” chronic diseases – a goal shared by THYRAGE. Indeed in vivo mice studies have been shown to support this hypothesis.

Anne’s favourite talks were during the imaging symposium dedicated to the late Professor Judith Adams whose clinical and research expertise lay particularly in the field of bone densitometry, quantitative computed tomography and vertebral fracture recognition. The images of high resolution micro CT imaging of bone and soft tissue simultaneously, including synchrotron x-ray phase contrast imaging of vascular channel networks in bone and finite element modelling captivated her and she now hopes for a chance to analyse bone in this way!

There was also a debate regarding whether fracture should be the only endpoint for osteoporosis trials. It had good for and against arguments and really made us think. It was a well-organised, interesting and fun meeting for both scientists and clinicians, with a wide range of bone-related topics discussed.
Website BRS Annual meeting 2018